What is msm used for




















The influence of methylsulfonylmethane on inflammation-associated cytokine release before and following strenuous exercise. Sports Med. Borzelleca J. Clarke T. Trends in the use of complementary health approaches among adults: United states, — Health Stat. Kantor E. Association between use of specialty dietary supplements and c-reactive protein concentrations.

Wall G. A pilot study of complementary and alternative medicine use in patients with fibromyalgia syndrome. Sievert S. The sulfur cycle; pp. Bentley R.

Environmental voscs——Formation and degradation of dimethyl sulfide, methanethiol and related materials. Boucher O. Dms atmospheric concentrations and sulphate aerosol indirect radiative forcing: A sensitivity study to the dms source representation and oxidation. Jorgensen S. Effect of hydration on the hydrogen abstraction reaction by ho in dms and its oxidation products. Kastner J. Catalytic ozonation of gaseous reduced sulfur compounds using wood fly ash.

Qiao L. Potential particulate pollution derived from uv-induced degradation of odorous dimethyl sulfide. Formation pathways of DMSO 2 in the addition channel of the oh-initiated dms oxidation: A theoretical study. Watts S. Measurements of the aerosol concentrations of methanesulphonic acid, dimethyl sulphoxide and dimethyl sulphone in the marine atmosphere of the british isles.

Charlson R. Oceanic phytoplankton, atmospheric sulphur, cloud albedo and climate. Lee P. A review of dimethylsulfoxide in aquatic environments. Harvey G. Dimethylsulfoxide and dimethylsulfone in the marine atmosphere. Smale B. Fate and metabolism of dimethyl sulfoxide in agricultural crops.

Endoh T. The sigmadependent transcriptional activator sfnr regulates the expression of the pseudomonas putida sfnfg operon responsible for dimethyl sulphone utilization. A cysb-regulated and sigmadependent regulator, sfnr, is essential for dimethyl sulfone metabolism of pseudomonas putida strain ds1. Characterization and identification of genes essential for dimethyl sulfide utilization in pseudomonas putida strain ds1. Habe H. Transcriptional regulation of the sulfate-starvation-induced gene sfna by a sigmadependent activator of pseudomonas putida.

Kouzuma A. The ptsp gene encoding the pts family protein ei Ntr is essential for dimethyl sulfone utilization by pseudomonas putida. FEMS Microbiol. Transcription factors cysb and sfnr constitute the hierarchical regulatory system for the sulfate starvation response in pseudomonas putida.

Pearson T. Naturally occurring levels of dimethyl sulfoxide in selected fruits, vegetables, grains, and beverages. Food Chem. Winning H.

An exploratory nmr nutri-metabonomic investigation reveals dimethyl sulfone as a dietary biomarker for onion intake. Moazzami A. Nuclear magnetic resonance-based metabolomics enable detection of the effects of a whole grain rye and rye bran diet on the metabolic profile of plasma in prostate cancer patients. Bennet R. Miscellaneous seperation processes. In: Perry R. Firn R.

Chapter 4: Are natural products different from synthetic chemicals? Silva Ferreira A. Influence of some technological parameters on the formation of dimethyl sulfide, 2-mercaptoethanol, methionol, and dimethyl sulfone in port wines. Kawakami M. Formation of aroma components in roasted or pan-fired green tea by roasting or pan-firing treatment.

Nippon Nogeikagaku Kaishi. Engelke U. Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional 1 H and two-dimensional 1 H- 13 C NMR. NMR Biomed. Gerhards E. The metabolism of dimethyl sulfoxide and its metabolic effects in man and animals. Metabolic fingerprint of dimethyl sulfone DMSO 2 in microbial—mammalian co-metabolism. Proteome Res. Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat.

Yde C. Effects of high dietary fibre diets formulated from by-products from vegetable and agricultural industries on plasma metabolites in gestating sows. Simpson H. Review article: Dietary fibre—microbiota interactions. Gut microbiota modification: Another piece in the puzzle of the benefits of physical exercise in health? Pinto J. Following healthy pregnancy by nmr metabolomics of plasma and correlation to urine. Magnuson B. Pharmacokinetics and distribution of 35S methylsulfonylmethane following oral administration to rats.

Otsuki S. Elucidation of dimethylsulfone metabolism in rat using a 35S radioisotope tracer method. Krieger D. Layman D. The absorption, metabolism and excretion of dimethyl sulfoxide by rhesus monkeys. Life Sci. Zhang Y. Urine-derived key volatiles may signal genetic relatedness in male rats.

Mattina M. Identification of volatile components of bobcat lynx rufus urine. Burger B. Elemental sulfur identified in urine of cheetah, acinonyx jubatus. Apps P. Identification of volatiles from the secretions and excretions of african wild dogs lycaon pictus J. Dawiskiba T. Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases. World J. Takeuchi A. Determination of dimethyl sulfoxide and dimethyl sulfone in urine by gas chromatography-mass spectrometry after preparation using 2, 2-dimethoxypropane.

Coppa M. Effect of a hay-based diet or different upland grazing systems on milk volatile compounds. Bakke J. Volatile compounds from the red deer cervus elaphus secretion from the tail gland. Figueira J. Nmr analysis of the human saliva metabolome distinguishes dementia patients from matched controls. Cecil K. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: Effects of dietary supplementation.

Lin A. Accumulation of methylsulfonylmethane in the human brain: Identification by multinuclear magnetic resonance spectroscopy. Rogovin J. Rosea S. Detection of dimethyl sulfone in the human brain by in vivo proton magnetic resonance spectroscopy. Willemsen M. Methylsulfonylmethane MSM ingestion causes a significant resonance in proton magnetic resonance spectra of brain and cerebrospinal fluid.

Waring R. The genetic origin of responses to drugs. Kistler M. Effects of diet-matrix on volatile organic compounds in breath in diet-induced obese mice. Breath Res. Martin W. Bloomer R. Serum msm concentrations following one month of msm treatment in healthy men.

Joung Y. Kim Y. The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages.

Kloesch B. Christian F. Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold spring harb perspect biol 1: A Cold Spring Harb. Ahn H. Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Oshima Y. The effect of distilled methylsulfonylmethane msm on human chondrocytes in vitro. Tousoulis D. The role of nitric oxide on endothelial function. Coleman J. Nitric oxide: A regulator of mast cell activation and mast cell-mediated inflammation.

Abderrazak A. NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases. Redox Biol. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem. Dunn J. Reactive oxygen species and mitochondria: A nexus of cellular homeostasis. Beilke M. Effects of dimethyl sulfoxide on the oxidative function of human neutrophils. Kastl L. FEBS Lett. Lim E. Nipin S. BMC Cancer. Dickson B. Ros signaling by nadph oxidase 5 modulates the proliferation and survival of prostate carcinoma cells.

Redza-Dutordoir M. Activation of apoptosis signalling pathways by reactive oxygen species. Acta Mol. Cell Res. Manea A. Gross A. BCL-2 family proteins as regulators of mitochondria metabolism. Karabay A. Liu D. P53, oxidative stress, and aging. Redox Signal. Kim S. Msm ameliorates HIV-1 tat induced neuronal oxidative stress via rebalance of the glutathione cycle.

Zhang H. Oxidative stress response and nrf2 signaling in aging. Free Radic. Role of NRF2 in oxidative stress and toxicity. Grimble R. The effects of sulfur amino acid intake on immune function in humans. Parcell S. Sulfur in human nutrition and applications in medicine. Ramoutar R. Antioxidant and anticancer properties and mechanisms of inorganic selenium, oxo-sulfur, and oxo-selenium compounds. Cell Biochem. Gabay C. Interleukin-6 and chronic inflammation. Arthritis Res. Candussio L.

Dimethyl sulfoxide inhibits histamine release induced by various chemicals. Agents Actions. Growth inhibitory effects of dimethyl sulfoxide and dimethyl sulfone on vascular smooth muscle and endothelial cells in vitro. In Vitro Cell. Alam S. Dimethyl sulfoxide inhibition of prostacyclin production in cultured aortic endothelial cells. Jafari N. Kim J. Methylsulfonylmethane suppresses hepatic tumor development through activation of apoptosis. Methylsulfonylmethane induces P53 independent apoptosis in HCT colon cancer cells.

Caron J. Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue-part i: Murine 4t1 66CL-4 cell line. Methyl sulfone blocked multiple hypoxia-and non-hypoxia-induced metastatic targets in breast cancer cells and melanoma cells. Touchberry C. Methylsulfonylmethane MSM treatment enhances C 2 C 12 wound closure and protects cells from oxidative stress. Methyl sulfone induces loss of metastatic properties and reemergence of normal phenotypes in a metastatic cloudman s M3 murine melanoma cell line.

Methyl sulfone manifests anticancer activity in a metastatic murine breast cancer cell line and in human breast cancer tissue-part 2: Human breast cancer tissue. Richmond V. Incorporation of methylsulfonylmethane sulfur into guinea pig serum proteins.

Stomach upset, diarrhea and headache have been reported in human trials of MSM lasting up to 12 weeks. However, people taking a placebo also reported similar symptoms. Since little is known about the long-term safety of MSM , it's no surprise that the efficacy also is unclear. Some studies have shown slight improvements in arthritis symptoms, but these studies were small and short term, so no definitive conclusions can be made.

Although there is great interest in using MSM to treat a variety of conditions, including arthritis, more research is needed to determine its benefits and risks. Brent A. Bauer, M. There is a problem with information submitted for this request. Sign up for free, and stay up-to-date on research advancements, health tips and current health topics, like COVID, plus expert advice on managing your health. Error Email field is required. Error Include a valid email address. To provide you with the most relevant and helpful information and to understand which information is beneficial, we may combine your e-mail and website usage information with other information we have about you.

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Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised. A single copy of these materials may be reprinted for noncommercial personal use only. This content does not have an English version. This content does not have an Arabic version. Sulfur compounds such as MSM play important roles in the health of your immune system For example, MSM may be effective in reducing oxidative stress and inflammation that can weaken immunity.

It may also help increase levels of this important compound. Having adequate levels of glutathione is crucial for the overall health and function of your immune system A test-tube study showed that MSM effectively restored glutathione levels and reduced inflammatory markers in mouse cells that had been weakened with HIV proteins MSM may help boost your immune system by reducing inflammation and increasing glutathione levels.

It contains high levels of the sulfur-containing amino acid cysteine. MSM may be beneficial for skin health by acting as a sulfur donor to keratin. This, in turn, can help strengthen this important protein. MSM also helps reduce inflammation, which can damage skin cells and cause signs of premature aging like wrinkles It may even reduce symptoms of problematic skin conditions such as rosacea, which can cause redness, irritation and inflammation of the skin.

One study showed that, when applied to the skin, MSM significantly improved redness, itching, inflammation, hydration and skin color in people with rosacea MSM may improve skin health by strengthening keratin and reducing inflammation.

It could even help reduce symptoms of certain skin conditions, as well. One of the newest areas of research involving MSM is studying its effectiveness in fighting cancer cells. Although the research is limited, the results have been promising so far. Several test-tube studies have shown that MSM inhibits the growth of stomach, esophageal, liver, colon, skin and bladder cancer cells 23 , 24 , 25 , 26 , It seems to do this by damaging cancer cell DNA and stimulating cancer cell death MSM also appears to prevent the spread of cancer cells, also known as metastasis A study in mice with liver cancer showed that those injected with MSM had fewer tumors, smaller tumor size and less liver damage than those who did not receive the treatment Another mouse study demonstrated that MSM inhibited the growth of human breast cancer cells Although these results are encouraging, more research is needed to determine the safety and efficacy of using MSM in cancer treatment.

Research has shown that MSM exhibits cancer-fighting properties in test-tube and animal studies, but more research is needed.

Numerous toxicity studies have been done to assess the safety of MSM and doses up to 4, However, some people may experience mild reactions if they are sensitive to MSM, such as stomach issues like nausea, bloating and diarrhea. When applied to the skin, it may also cause mild skin or eye irritation 33 , Additionally, there is concern over mixing MSM with alcohol since other sulfur-containing medications can cause adverse reactions when mixed with alcoholic beverages MSM supplements are generally considered safe.

However, they may cause side effects like nausea, diarrhea and skin reactions in some people. Research shows that it may be helpful in reducing joint pain, lowering inflammation, improving skin health, decreasing allergy symptoms and speeding recovery after exercise. Additionally, some evidence suggests that MSM can boost the immune system and may have cancer-fighting properties.

Although the current findings on MSM are promising, more research is needed to understand all of its potential benefits as well as possible side effects. Some supplements can have powerful effects. Here is a list of 4 natural supplements that are just as effective as pharmaceutical drugs. Inflammation is one of the leading drivers of many common diseases. Here are 10 supplements that can reduce inflammation, backed by science. Chronic inflammation can lead to weight gain and disease.



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